Why do we have privileged sites

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Your Face-to-Face Program Digitized. Scalable support networks. Back to resources. Diversity and Inclusion 5 main types of privilege Behind every privilege is an imbalance of power.

Privilege describes benefits that belong to people because they fit into a specific social group or have certain dimensions to their identity. You can have or lack privilege because of your race, gender, sexual orientation, ability, religion, wealth, and class, among many other characteristics.

You may not even notice it until you educate yourself about its existence. Download citation. Received : 10 July Issue Date : 11 October Anyone you share the following link with will be able to read this content:.

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Abstract WHEN solid tissue allografts are transplanted orthotopically to alien hosts they are rejected with a characteristic tempo and vigour that depends primarily on the immunogenetic disparity between donor and host. Access through your institution. Buy or subscribe. Rent or Buy article Get time limited or full article access on ReadCube.

References 1 Murphy, J. Google Scholar 3 Woodruff, M. The eye is one of a few areas of the body with immune privilege. Other sites with immune privilege include the brain, testes, placenta and fetus. Because of this immune privilege, the eye offers an excellent location for certain kinds of research and therapy. For example, scientists can implant types of cells called stem cells in the eye to study their role in regrowing or repairing damaged tissue.

Cells implanted in the immune-privileged eye are less likely to be rejected than they might be in other parts of the body. Studies of stem cell use in the eye have shown promise in treating vision loss. Another reason the eye is a good place for researching new therapies? It is relatively easy to reach and see inside of the structure. Sugerman, P. The pathogenesis of oral lichen planus. Geerts, A. History, heterogeneity, developmental biology, and functions of quiescent hepatic stellate cells.

Liver Dis. Khanna, A. Effects of liver-derived dendritic cell progenitors on Th1- and Th2-like cytokine responses in vitro and in vivo.

Westgate, G. Immune privilege in hair growth. Ito, T. Maintenance of hair follicle immune privilege is linked to prevention of NK cell attack. Collapse and restoration of MHC class-I-dependent immune privilege: exploiting the human hair follicle as a model. Christoph, T. The human hair follicle immune system: cellular composition and immune privilege. Alvarez, D. Th2 differentiation in distinct lymph nodes influences the site of mucosal Th2 immune-inflammatory responses.

Wilbanks, G. Evidence that an antigen-specific, ACAID-inducing, cell-associated signal exists in the peripheral blood. Takahashi, M. Stein-Streilein, J. Cross talk among cells promoting anterior chamber-associated immune deviation. Sonoda, K. Ocular immune privilege and CD1d-reactive natural killer T cells. Cornea 21, S33—38 Skelsey, M. Gamma delta T cells are needed for ocular immune privilege and corneal graft survival. Role of splenic B cells in the immune privilege of the anterior chamber of the eye.

Guller, S. Role of Fas ligand in conferring immune privilege to non-lymphoid cells. Arcuri, F. Human decidual natural killer cells as a source and target of macrophage migration inhibitory factor.

Reproduction , — Menier, C. The role of HLA-G in human pregnancy. Katz, J. Indoleamine 2,3-dioxygenase in T-cell tolerance and tumoral immune escape. Cabestre, F. HLA-G expression: immune privilege for tumour cells? Cancer Biol. Linkermann, A. Considering Fas ligand as a target for therapy.

Expert Opin. Targets 9, — Minas, V. Cancer 97, — Curiel, T. Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival. Juszczynski, P. The AP1-dependent secretion of galectin-1 by Reed Sternberg cells fosters immune privilege in classical Hodgkin lymphoma.

Natl Acad. USA , — Wahl, S. TGF-beta: a mobile purveyor of immune privilege. Munn, D. The tumor-draining lymph node as an immune-privileged site. Ishida, T. Specific recruitment of CC chemokine receptor 4-positive regulatory T cells in Hodgkin lymphoma fosters immune privilege.

Cancer Res. Peters, N. Immune privilege in sites of chronic infection: Leishmania and regulatory T cells. Lepisto, A. How herpes simplex virus type 1 rescinds corneal privilege. Persidsky, Y. Singh, N. Primer: mechanisms of immunologic tolerance.

Anderson, M. The cellular mechanism of Aire control of T cell tolerance. Immunity 23, — Ferguson, B. Egwuagu, C. Thymic expression of autoantigens correlates with resistance to autoimmune disease. DeVoss, J. Spontaneous autoimmunity prevented by thymic expression of a single self-antigen. Immunopathology of the eye. Mouse models of experimental autoimmune uveitis.

Lambe, T. CD4T cell-dependent autoimmunity against a melanocyte neoantigen induces spontaneous vitiligo and depends upon Fas—Fas ligand interactions. Limited peripheral T cell anergy predisposes to retinal autoimmunity. Sosnova, M. Stem Cells 23, — Class II major histocompatibility complex Ia antigen-bearing dendritic cells within the iris and ciliary body of the rat eye: distribution, phenotype and relation to retinal microglia.

Immunology 77, — Distribution and phenotype of dendritic cells and resident tissue macrophages in the dura mater, leptomeninges, and choroid plexus of the rat brain as demonstrated in wholemount preparations. Identification of novel dendritic cell populations in normal mouse retina. Dudziak, D. Differential antigen processing by dendritic cell subsets in vivo.

Nussenzweig, M. A monoclonal antibody specific for mouse dendritic cells. USA 79, — Hill, M. Nitric oxide and indoleamine 2,3-dioxygenase mediate CTLA4Ig-induced survival in heart allografts in rats.

Transplantation 84, — Rossner, S. Myeloid dendritic cell precursors generated from bone marrow suppress T cell responses via cell contact and nitric oxide production in vitro. Yamada, J. Zhang-Hoover, J. Therapies based on principles of ocular immune privilege. Katagiri, K. Using tolerance induced via the anterior chamber of the eye to inhibit Th2-dependent pulmonary pathology.

Intermediate and posterior uveitis. Daley, S. A key role for TGF-beta signaling to T cells in the long-term acceptance of allografts. Yates, S. Induction of regulatory T cells and dominant tolerance by dendritic cells incapable of full activation. Mitchison, N. Matzinger, P. The danger model: a renewed sense of self. Janeway, C. Innate immune recognition. Simpson, E.

A historical perspective on immunological privilege. An innate sense of danger. Immune privilege in the testis. Evaluation of potential local factors. Transplantation 40, — Basic parameters of allograft survival. Transplantation 36, — Kersh, G. Transcriptional control of thymocyte positive selection. Matsumoto, M. Transcriptional regulation in thymic epithelial cells for the establishment of self tolerance. Hollander, G.